The role of the pathologist in diagnosing and grading biliary diseases.

  title={The role of the pathologist in diagnosing and grading biliary diseases.},
  author={Yasuni Nakanuma and Kazuho Harada},
  journal={Clinics and research in hepatology and gastroenterology},
  volume={35 5},
Pathological features of primary biliary cirrhosis (PBC) are reviewed. Immune-mediated, non-suppurative cholangitis is the initial lesion and is followed by the gradual and extensive destruction of bile ducts and development of chronic cholestasis. Simultaneously, necro-inflammatory activities of the hepatic parenchyma and limiting plates of milder form develop not infrequently. Eventually, liver fibrosis and cirrhosis develop. A new system applicable to needle liver biopsies in which staging… CONTINUE READING


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