The role of the multifunctional peptide LL-37 in host defense.

  title={The role of the multifunctional peptide LL-37 in host defense.},
  author={Ylva Kai-Larsen and Birgitta Agerberth},
  journal={Frontiers in bioscience : a journal and virtual library},
Neutrophil granules contain several antimicrobial peptides (AMPs) that are important effector molecules of innate immunity. In mammals, the main families of these peptides are the cathelicidins and defensins. Several defensins have been characterized in humans, while there is only one human cathelicidin, designated LL-37. This peptide is stored in specific granules of neutrophils in an inactive proform, which is processed extracellularly to the mature active peptide LL-37 and the propart… CONTINUE READING
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