The role of the microsomal triglygeride transfer protein in abetalipoproteinemia.

  title={The role of the microsomal triglygeride transfer protein in abetalipoproteinemia.},
  author={Nathalie Berriot-Varoqueaux and Lawrence P. Aggerbeck and Marie-Elizabeth Samson-Bouma and John R. Wetterau},
  journal={Annual review of nutrition},
The microsomal triglyceride transfer protein (MTP) is a dimeric lipid transfer protein consisting of protein disulfide isomerase and a unique 97-kDa subunit. In vitro, MTP accelerates the transport of triglyceride, cholesteryl ester, and phospholipid between membranes. It was recently demonstrated that abetalipoproteinemia, a hereditary disease characterized as an inability to produce chylomicrons and very low-density lipoproteins in the intestine and liver, respectively, results from mutations… CONTINUE READING
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