The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides.

@article{Zhu2001TheRO,
  title={The role of the macrophage scavenger receptor in immune stimulation by bacterial DNA and synthetic oligonucleotides.},
  author={F G Zhu and Charles F. Reich and David S. Pisetsky},
  journal={Immunology},
  year={2001},
  volume={103 2},
  pages={226-34}
}
To assess the role of the macrophage scavenger receptor type A (SRA) in immune activation by CpG DNA, cytokine induction and DNA uptake were tested in vitro and in vivo using SRA knockout (SRA-/-) and wild type (WT) mice. As a source of CpG DNA, Escherichia coli DNA (EC DNA) and a 20-mer phosphorothioate oligodeoxynucleotide with two CpG motifs (CpG ODN) were used. In vitro, both EC DNA and the CpG ODN induced dose-dependent increases of interleukin (IL)-12 production by spleen cells and bone… CONTINUE READING