The role of the kidney in the biosynthesis of carnitine in the rat.

@article{Carter1979TheRO,
  title={The role of the kidney in the biosynthesis of carnitine in the rat.},
  author={Alva Lee Carter and Rene Frenkel},
  journal={The Journal of biological chemistry},
  year={1979},
  volume={254 21},
  pages={10670-4}
}
Intravenous administration of L-[methyl-3H]-labeled trimethyllysine to rats results in a very rapid accumulation of radioactivity by the kidneys, while the incorporation of the label into the liver occurs at approximately 1% of this rate when calculated per g of wet tissue. The kidneys convert a substantial portion of the trimethyllysine taken up to butyrobetaine and to beta-hydroxytrimethyllysine, a precursor of butyrobetaine, but fail to synthesize carnitine. Significant amounts of… CONTINUE READING

References

Publications referenced by this paper.
Showing 1-2 of 2 references

hp://w w w .jb.org/ D ow nladed from A L Carter and R Frenkel The role of the kidney in the biosynthesis of carnitine in the rat

  • J. H. LaBadie, W. A. Dunn, N. N. Aronson, Jr.
  • J. Biol. Chem
  • 1978

hp://w w w .jb.org/ D ow nladed from 10674 Role of Kidney in Carnitine Biosynthesis

  • D. W. Horne, V. Tanphraichitr, H. P. Broquist
  • J. Biol. Chem. 246,
  • 1971
1 Excerpt

Similar Papers

Loading similar papers…