The role of the intestine in the pathophysiology and management of severe acute pancreatitis.

@article{Flint2003TheRO,
  title={The role of the intestine in the pathophysiology and management of severe acute pancreatitis.},
  author={R. Flint and J. Windsor},
  journal={HPB : the official journal of the International Hepato Pancreato Biliary Association},
  year={2003},
  volume={5 2},
  pages={
          69-85
        }
}
  • R. Flint, J. Windsor
  • Published 2003
  • Medicine
  • HPB : the official journal of the International Hepato Pancreato Biliary Association
BACKGROUND The outcome of severe acute pancreatitis has scarcely improved in 10 years. Further impact will require new paradigms in pathophysiology and treatment. There is accumulating evidence to support the concept that the intestine has a key role in the pathophysiology of severe acute pancreatitis which goes beyond the notion of secondary pancreatic infection. Intestinal ischaemia and reperfusion and barrier failure are implicated in the development of multiple organ failure. DISCUSSION… Expand
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