The role of the intestinal microflora in the formation of mutagenic metabolites from the carcinogenic air pollutant 2-nitrofluorene.

@article{Mller1988TheRO,
  title={The role of the intestinal microflora in the formation of mutagenic metabolites from the carcinogenic air pollutant 2-nitrofluorene.},
  author={Lennart M{\"o}ller and M Corrie and Tore Midtvedt and Joseph Rafter and Jan Ake Gustafsson},
  journal={Carcinogenesis},
  year={1988},
  volume={9 5},
  pages={823-30}
}
After a single oral dose of 2-nitro[9-14C]fluorene (NF) to germfree and conventional rats, radioactivity with associated mutagenic activity was rapidly excreted in both urine and feces. The mutagenicity excreted from germfree animals exceeded the mutagenicity excreted from conventional animals. Absence of the microflora resulted in lack of nitroreduction and excreted metabolites from germfree rats were mono- or dihydroxylated nitrofluorenes, as assessed by liquid chromatography/mass… CONTINUE READING