The role of the inflammasome in cellular responses to toxins and bacterial effectors

  title={The role of the inflammasome in cellular responses to toxins and bacterial effectors},
  author={Barbara Fr{\^e}che and N{\'u}ria Reig and F. Gisou van der Goot},
  journal={Seminars in Immunopathology},
Invading pathogens are recognized by mammalian cells through dedicated receptors found either at the cell surface or in the cytoplasm. These receptors, like the trans-membrane Toll-like Receptors (TLR) or the cytosolic Nod-like Receptors (NLR), initiate innate immunity after recognition of molecular patterns found in bacteria or viruses, such as LPS, flagellin, or double-stranded RNA. Recognition of molecules produced only by a specific pathogen, such as a viral envelop protein or a bacterial… CONTINUE READING


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