The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.

@article{Gerspach2011TheRO,
  title={The role of the gut sweet taste receptor in regulating GLP-1, PYY, and CCK release in humans.},
  author={A C Gerspach and Robert E Steinert and Lucia Schoenenberger and Angelika Graber-Maier and Christoph Beglinger},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2011},
  volume={301 2},
  pages={E317-25}
}
The recent identification of sweet taste receptors in the gastrointestinal tract has important implications in the control of food intake and glucose homeostasis. Lactisole can inhibit the sweet taste receptor T1R2/T1R3. The objective was to use lactisole as a probe to investigate the physiological role of T1R2/T1R3 by assessing the effect of T1R2/T1R3 blockade on GLP-1, PYY, and CCK release in response to 1) intragastric administration of nutrients or 2) intraduodenal perfusion of nutrients… CONTINUE READING