The role of the gut in the development of sepsis in acute pancreatitis.

  title={The role of the gut in the development of sepsis in acute pancreatitis.},
  author={Norbert S. F. Runkel and Frank Moody and G. Stevenson Smith and Luis F. Rodriguez and Mark T. Larocco and Thomas A. Miller},
  journal={The Journal of surgical research},
  volume={51 1},
The pathogenesis of sepsis in acute pancreatitis is unknown. Since the intestinal tract has recently been identified as a possible source for sepsis in other conditions, we explored whether the gut may serve as a reservoir for bacteria causing systemic and pancreatic infection in acute pancreatitis. Bacterial translocation, alterations of intestinal microflora, and intestinal motility, as reflected by gut propulsion, were studied in a rat pancreatitis model. Acute pancreatitis was induced by… CONTINUE READING
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