The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.

  title={The role of the gastric afferent vagal nerve in ghrelin-induced feeding and growth hormone secretion in rats.},
  author={Yukari Date and Noboru Murakami and Koji Toshinai and Shigeru Matsukura and Akira Niijima and Hisayuki Matsuo and Kenji Kangawa and Masamitsu Nakazato},
  volume={123 4},
BACKGROUND & AIMS Visceral sensory information is transmitted to the brain through the afferent vagus nerve. Ghrelin, a peptide primarily produced in the stomach, stimulates both feeding and growth hormone (GH) secretion. How stomach-derived ghrelin exerts these central actions is still unknown. Here we determined the role of the gastric afferent vagal nerve in ghrelin's functions. METHODS Food intake and GH secretion were examined after an administration of ghrelin intravenously (IV) to rats… 

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Ghrelin, which is negatively regulated by leptin and IL-1 beta, is secreted by the stomach and increases arcuate NPY expression, which in turn acts through Y(1) receptors to increase food intake and decrease energy expenditure.
A role for ghrelin in the central regulation of feeding
It is shown that ghrelin is involved in the hypothalamic regulation of energy homeostasis and probably has a function in growth regulation by stimulating feeding and release of growth hormone.
Ghrelin, an endogenous growth hormone secretagogue, is a novel orexigenic peptide that antagonizes leptin action through the activation of hypothalamic neuropeptide Y/Y1 receptor pathway.
Evidence is provided that ghrelin is an orexigenic peptide that antagonizes leptin action through the activation of hypothalamic NPY/Y1 receptor pathway and is effective in growth hormone-deficient spontaneous dwarf rats.
The novel hypothalamic peptide ghrelin stimulates food intake and growth hormone secretion.
It is found that both intracerebroventricular and intraperitoneal administration of ghrelin in freely feeding rats stimulated food intake and plasma growth hormone (GH) concentration increased following both i.c.v. and i.p. administration.
Relationships between gastric motility and gastric vagal afferent responses to CCK and GRP in rats differ.
Results suggest that GRP-(18-27) activates gastric vagal afferents secondary to its stimulation of gastric motor effects, suggesting a direct action of CCK at functional vagal CCK receptors.
Ghrelin, a novel growth hormone-releasing acylated peptide, is synthesized in a distinct endocrine cell type in the gastrointestinal tracts of rats and humans.
Ghrelin probably functions not only in the control of GH secretion, but also in the regulation of diverse processes of the digestive system, and its findings provide clues to additional physiological functions of this novel gastrointestinal hormone.
Ghrelin enhances appetite and increases food intake in humans.
  • A. WrenL. Seal S. Bloom
  • Medicine, Biology
    The Journal of clinical endocrinology and metabolism
  • 2001
Ghrelin is the first circulating hormone demonstrated to stimulate food intake in man and is a potentially important new regulator of the complex systems controlling food intake and body weight.
Endocrine activities of ghrelin, a natural growth hormone secretagogue (GHS), in humans: comparison and interactions with hexarelin, a nonnatural peptidyl GHS, and GH-releasing hormone.
Ghrelin, a natural ligand of GHS-receptor, exerts a strong stimulatory effect on GH secretion in humans, releasing more GH than GHRH and even more than a nonnatural GHS such as HEX, which possesses strong GH-releasing activity but also significantly stimulates PRL, ACTH, and cortisol secretion.
Ghrelin strongly stimulates growth hormone release in humans.
This is the first study showing evidence that ghrelin strongly stimulates GH release in humans, and the lowest dose resulted in only minimum peak values of these hormones.