The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.

@article{Einat2003TheRO,
  title={The role of the extracellular signal-regulated kinase signaling pathway in mood modulation.},
  author={Haim Einat and Peixiong Yuan and Todd D. Gould and Jianling Li and Jianhua Du and Lei Zhang and Husseini K. Manji and Guang Chen},
  journal={The Journal of neuroscience : the official journal of the Society for Neuroscience},
  year={2003},
  volume={23 19},
  pages={7311-6}
}
The neurobiological underpinnings of mood modulation, molecular pathophysiology of manic-depressive illness, and therapeutic mechanism of mood stabilizers are largely unknown. The extracellular signal-regulated kinase (ERK) pathway is activated by neurotrophins and other neuroactive chemicals to produce their effects on neuronal differentiation, survival, regeneration, and structural and functional plasticity. We found that lithium and valproate, commonly used mood stabilizers for the treatment… CONTINUE READING
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Manic-depressive illness. New York: Oxford UP

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