The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse.

@article{Endres2016TheRO,
  title={The role of the equilibrative nucleoside transporter 1 on tissue and fetal distribution of ribavirin in the mouse.},
  author={Christopher J Endres and Aaron Moss and Kazuya Ishida and Rajgopal Govindarajan and Jashvant D. Unadkat},
  journal={Biopharmaceutics & drug disposition},
  year={2016},
  volume={37 6},
  pages={336-44}
}
Ribavirin is used for the treatment of hepatitis C virus (HCV) infection. The equilibrative nucleoside transporter 1 (ENT1) expressed in hepatocytes transports ribavirin into the liver, the site of efficacy of the drug. However, it is still unclear whether ENT1 plays a dominant role in the hepatic distribution of the drug in vivo. In addition, due to fetal… CONTINUE READING