The role of the epidermis and the mechanism of action of occlusive dressings in scarring.

@article{Mustoe2011TheRO,
  title={The role of the epidermis and the mechanism of action of occlusive dressings in scarring.},
  author={Thomas A. Mustoe and Anandev N. Gurjala},
  journal={Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society},
  year={2011},
  volume={19 Suppl 1},
  pages={s16-21}
}
The problem of cutaneous scarring has conventionally been approached as a pathology of the dermis. Multiple lines of evidence from the clinic, in vitro experiments, and in vivo animal and human studies, however, increasingly suggest that the epidermis plays a major role in the control of underlying dermal scar. Building on the demonstrated efficacy of silicone gel occlusion, in this paper we review the evidence for epidermal regulation of scar, and propose the novel hypothesis that dermal… CONTINUE READING

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