The role of the epicardium and neural crest as extracardiac contributors to coronary vascular development.

@article{Poelmann2002TheRO,
  title={The role of the epicardium and neural crest as extracardiac contributors to coronary vascular development.},
  author={Robert E. Poelmann and Heleen Lie-Venema and Adriana C. Gittenberger-de Groot},
  journal={Texas Heart Institute journal},
  year={2002},
  volume={29 4},
  pages={255-61}
}
At species-specific times in embryonic development, the pro-epicardial organ appears as an outcropping of the mesothelial body wall, near the sinus venosus-liver region. The pro-epicardial vesicles attach to the myocardium, flatten, and join to form the epicardium. The epicardium shows epithelial-mesenchymal transformation: cells detach from the epithelium, fill the subepicardial space, and invade the heart tube. Epicardium-derived cells migrate as far as the core of the endocardial cushions… CONTINUE READING

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