The role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population.

@article{Kreutz2005TheRO,
  title={The role of the cytochrome P450 3A5 enzyme for blood pressure regulation in the general Caucasian population.},
  author={Reinhold Kreutz and Mike W Zuurman and Silke Kain and Juliane Bolbrinker and Paul E. de Jong and Gerjan Navis},
  journal={Pharmacogenetics and genomics},
  year={2005},
  volume={15 12},
  pages={831-7}
}
Cytochrome P450 3A (CYP3A) enzymes are important for drug metabolism in gut and liver. The CYP3A5 isoenzyme is also expressed in the kidney and has been implicated in renal sodium reabsorption and blood pressure regulation. Its expression and activity is strongly linked to a polymorphism (i.e. 6986G > A). Thus, appreciable expression is found in carriers of the CYP3A5*1 (6986A) but not in homozygous carriers of the CYP3A5*3 (6986G) allele. We tested whether the presence of CYP3A5*1 affects… CONTINUE READING

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