The role of the complement system in innate immunity

@article{Rus2005TheRO,
  title={The role of the complement system in innate immunity},
  author={Horea G Rus and Cornelia D Cudrici and Florin Niculescu},
  journal={Immunologic Research},
  year={2005},
  volume={33},
  pages={103-112}
}
Complement is a major component of innate immune system involved in defending against all the foreign pathogens through complement fragments that participate in opsonization, chemotaxis, and activation of leukocytes and through cytolysis by C5b-9 membrane attack complex. Bacterias and viruses have adapted in various ways to escape the complement activation, and they take advantage of the complement system by using the host complement receptors to infect various cells. Complement activation also… 
The Complement System
TLDR
Because of its functions, complement system is an attractive therapeutic target for a wide range of diseases, and its modulation could constitute a viable therapeutic strategy for the treatment of autoimmune conditions too.
Complement and Adaptive Immunity: Roles for the Anaphylatoxins C3a and C5a in Regulating Tumor Immunity
TLDR
In this review, the most recent evidence illustrating the role of the complement system in adaptive immunity and cancer will be discussed, and some questions will be raised as to whether some complement components can enhance the efficacy of cancer immunotherapy due to their influence on adaptive immunity.
Complement and autoimmunity
TLDR
Data from preclinical studies and initial clinical trials suggest that the modulation of the complement system could constitute a viable strategy for the treatment of autoimmune conditions in the decades to come.
Complement Deficiencies in Systemic Lupus Erythematosus
TLDR
The goal of this review will be to discuss the associations between and the causal mechanisms of complement deficiencies and systemic lupus erythematosus.
Complement: an overview for the clinician.
TLDR
The complement system is an essential component of the immune system and has a number of functions, including host defense, removal of injured cells and debris, modulation of metabolic and regeneration processes, and regulation of adaptive immunity.
On the Functional Overlap between Complement and Anti-Microbial Peptides
TLDR
Because of the therapeutic implications, this review will consider closely studies dealing with complement activation and anti-microbial peptide activity in acute inflammation (e.g., dialysis-related peritonitis, appendicitis, and ischemia).
Targeting complement cascade: an alternative strategy for COVID-19
TLDR
Pre-clinical and clinical studies evidence that the inhibition of complement components results in reduced complement deposits on target and non-target tissues, and aid in recovery from the pathological conditions of ARDS.
Targeted complement inhibition and microvasculature in transplants: a therapeutic perspective
TLDR
The mechanism that complement contributes to angiogenic injury, and the development of future therapeutic targets by antagonizing activated complement mediators to preserve microvasculature in rejecting the transplanted organ are discussed.
Formation and Maturation of the Phagosome: A Key Mechanism in Innate Immunity against Intracellular Bacterial Infection
TLDR
The immune evasion strategies used by pathogens to regulate phagosome maturation during intracellular bacterial infection are discussed and it is indicated that these might be used for the development of potential therapeutic strategies for infectious diseases.
Complement, infection, and autoimmunity.
TLDR
The relationship between the complement system and autoimmunity appears paradoxical as both the deficiency and the activation contribute to inducing autoimmune diseases.
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 59 REFERENCES
The role of complement in B cell activation and tolerance.
  • M. Carroll
  • Biology, Medicine
    Advances in immunology
  • 2000
TLDR
How the complement system, a major mediator of innate immunity, links the two systems is discussed, and a surprise that has come from analysis of the deficient mice is that complement is also important in negative selection of B lymphocytes.
Myeloid C3 Determines Induction of Humoral Responses to Peripheral Herpes Simplex Virus Infection 1
TLDR
Insight is offered into the generation of the adaptive immune response in the periphery and a unique role is described for a nonhepatic complement source during the induction of humoral responses to peripheral HSV infection.
Protective T Cell–Independent Antiviral Antibody Responses Are Dependent on Complement
TLDR
Absence of the early neutralizing antibody responses, together with the reduced efficiency of neutralizing IgM in C3−/− mice, led to a drastically enhanced susceptibility to disease after infection with VSV.
Primitive complement system--recognition and activation.
TLDR
Unexpectedly, the complement system of an invertebrate deuterostome, ascidian, shows a similar level of complexity as that of mammals, suggesting that expansion of complement genes by gene duplications occurred independently both in the ascidian and vertebrate lineages.
Impact of mannose-binding lectin on susceptibility to infectious diseases.
  • D. Eisen, R. Minchinton
  • Biology, Medicine
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2003
TLDR
Clinical studies have shown that MBL insufficiency is associated with bacterial infection in patients with neutropenia and meningococcal sepsis, and low MBL levels appear to predispose persons to HIV infection.
A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo.
TLDR
These results constitute the first demonstration of an impairment in the phagocytosis of apoptotic cells by macrophages in vivo in a mammalian system and may explain the link between hereditary complement deficiency and the development of SLE.
Availability of Complement Bound to Staphylococcus aureus To Interact with Membrane Complement Receptors Influences Efficiency of Phagocytosis
TLDR
Complement in normal human serum may have an important role in opsonizing encapsulated Staphylococcus aureus, even when capsule expression is strong.
Chemotaxis Inhibitory Protein of Staphylococcus aureus, a Bacterial Antiinflammatory Agent
TLDR
A new protein secreted by Staphylococcus aureus is described that specifically impairs the response of neutrophils and monocytes to formylated peptides and C5a, suggesting a new immune escape mechanism of S. aUREus and putting forward CHIPS as a potential new antiinflammatory therapeutic compound.
Inhibition of C5a-induced inflammation with preserved C5b-9-mediated bactericidal activity in a human whole blood model of meningococcal sepsis.
TLDR
The anti-C5a mAb 137-26 inhibits the potentially harmful effects of N meningitidis-induced C5a formation while preserving complement-mediated bacterial killing in a novel human whole blood model of meningococcal sepsis.
Complement-dependent Clearance of Apoptotic Cells by Human Macrophages
TLDR
In the presence of serum, the macrophage receptors for C3bi, CR3 and CR4, were significantly more efficient in the uptake of apoptotic cells compared with previously described receptors implicated in clearance.
...
1
2
3
4
5
...