The role of the complement cascade in ischemia/reperfusion injury: implications for neuroprotection.

@article{DAmbrosio2001TheRO,
  title={The role of the complement cascade in ischemia/reperfusion injury: implications for neuroprotection.},
  author={Anthony L. D'Ambrosio and David J. Pinsky and E. Sander Connolly},
  journal={Molecular medicine},
  year={2001},
  volume={7 6},
  pages={
          367-82
        }
}
BACKGROUND The complement cascade plays a deleterious role in multiple models of ischemia/reperfusion (I/R) injury, including stroke. Investigation of the complement cascade may provide a critical approach to identifying neuroprotective strategies that can be effective at clinically relevant time points in cerebral ischemia. This review of the literature describes the deleterious effects of complement activation in systemic I/R models and previous attempts at therapeutic complement inhibition… CONTINUE READING

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