The role of the classical complement cascade in synapse loss during development and glaucoma.

@article{Rosen2010TheRO,
  title={The role of the classical complement cascade in synapse loss during development and glaucoma.},
  author={Allison M Rosen and Beth Stevens},
  journal={Advances in experimental medicine and biology},
  year={2010},
  volume={703},
  pages={75-93}
}
Glaucoma is one of the leading causes of vision loss worldwide, yet the signals that initiate the progressive degeneration of optic nerve axons and the selective loss of retinal ganglion neurons (RGCs) remain elusive. Reactive gliosis, release of inflammatory cytokines, and complement upregulation all occur in the early stages of glaucoma in several disease models. Recent work has implicated the classical complement cascade in the elimination of excess synaptic connections in the developing… CONTINUE READING

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