The role of the cholinergic system in the development of the human cerebellum.

@article{Court1995TheRO,
  title={The role of the cholinergic system in the development of the human cerebellum.},
  author={Jenny A Court and Elaine K. Perry and D Spurden and Meryl H Griffiths and J M Kerwin and Christopher M Morris and Mary I. Johnson and Arthur Ernest Oakley and Nigel J. M. Birdsall and Francesco Clementi},
  journal={Brain research. Developmental brain research},
  year={1995},
  volume={90 1-2},
  pages={159-67}
}
High affinity (-)nicotine ([3H]nicotine), alpha-bungarotoxin ([125I]alpha-bungarotoxin) and muscarinic binding ([3H]N-methyl scopolamine) in the human cerebellum were compared between the foetal period (23-39 weeks gestation) and young adulthood (14-34 years) in an autoradiographic study. To estimate proportions of muscarinic receptor subtypes variable wash times and displacement with pirenzepine were employed. [3H]Nicotine binding and total muscarinic binding in foetuses exceeded that in young… CONTINUE READING

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