The role of the central cholinergic projections in cognition: implications of the effects of scopolamine on discrimination learning by monkeys.

@article{Harder1998TheRO,
  title={The role of the central cholinergic projections in cognition: implications of the effects of scopolamine on discrimination learning by monkeys.},
  author={Josie A Harder and Harry F. Baker and Rosalind M. Ridley},
  journal={Brain research bulletin},
  year={1998},
  volume={45 3},
  pages={319-26}
}
In humans, administration of the cholinergic antagonist scopolamine impairs the encoding of information into long-term memory and has effects on other cognitive processes. It has been supposed that it is inhibition of the rising cholinergic projections from the basal forebrain, specifically from the basal nucleus of Meynert (NBM) to the neocortex and from the medial septum/vertical limb of the diagonal band of Broca (MS/VDB) to the hippocampus, that results in these cognitive impairments. In… CONTINUE READING

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