The role of the calcium-dependent enzymes nitric oxide synthase and calpain in hypoxia-induced proximal tubule injury.

Abstract

A role of cytoplasmic free calcium [Ca2+]i in hypoxia-induced proximal tubule damage has been proposed. To further investigate the role of [Ca2+]i in mediating hypoxic proximal tubular injury, a video imaging technique has been developed in which [Ca2+]i can be measured simultaneously with propidium iodide (PI) staining of nuclei as an index of hypoxia… (More)

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