The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions.

@article{Mitsiades2006TheRO,
  title={The role of the bone microenvironment in the pathophysiology and therapeutic management of multiple myeloma: interplay of growth factors, their receptors and stromal interactions.},
  author={Constantine Mitsiades and Nicholas S Mitsiades and Nikhil C. Munshi and Paul G Richardson and Kenneth C. Anderson},
  journal={European journal of cancer},
  year={2006},
  volume={42 11},
  pages={1564-73}
}
The close relationship between the biological behaviour of malignant cells and the local microenvironment where they reside is a feature of diverse neoplasias. Multiple myeloma (MM) is considered a main disease model for the study of such interactions and the mechanisms that can lead to bone-related clinical complications, as well as the role of these interactions in attenuating the activity of conventional anti-MM therapeutics, such as dexamethasone and cytotoxic chemotherapeutics. This review… CONTINUE READING

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