The role of the autophagy in myocardial ischemia/reperfusion injury.

  title={The role of the autophagy in myocardial ischemia/reperfusion injury.},
  author={Sai Ma and Yabin Wang and Yundai Chen and Feng Cao},
  journal={Biochimica et biophysica acta},
  volume={1852 2},
Autophagy is an intracellular process responsible for damaged or unnecessary protein and organelle degradation. In the heart, autophagy occurs at basal level and dysregulated autophagy is associated with a variety of cardiovascular diseases. Autophagy is enhanced in ischemia as well as in the reperfusion phase during cardiac ischemia reperfusion (I/R) injury. More importantly, recent studies revealed that autophagy exerted both beneficial and detrimental effects in pathology of cardiac ischemia… CONTINUE READING
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P. Tannous, H. Zhu
Nemchenko, J.M. Berry, J.L. Johnstone, J.M. Shelton, F.J. Miller Jr., B.A. Rothermel, J.A. Hill, Intracellular protein aggregation is a proximal trigger of cardiomyocyte autophagy, Circulation 117 (2008) 3070–3078. ial ischemia/reperfusion injury, Biochim. Biophys. Acta (2014), http:// 6 S. Ma et • 2014
View 1 Excerpt


A. S. Go, D. Mozaffarian, +41 authors M. B. Turner
American Heart Association Statistics, S. Stroke Statistics, executive summary: heart disease and stroke statistics—2014 update: a report from the american heart association, Circulation 129 • 2014
View 1 Excerpt

Acetylcholine mediates AMPK-dependent autophagic cytoprotection in H9c2 cells during hypoxia/reoxygenation injury.

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology • 2013
View 1 Excerpt

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