The role of the anterior neural ridge and Fgf-8 in early forebrain patterning and regionalization in Xenopus laevis.

@article{Eagleson2002TheRO,
  title={The role of the anterior neural ridge and Fgf-8 in early forebrain patterning and regionalization in Xenopus laevis.},
  author={Gerald W Eagleson and Ryan Douglas Dempewolf},
  journal={Comparative biochemistry and physiology. Part B, Biochemistry & molecular biology},
  year={2002},
  volume={132 1},
  pages={179-89}
}
The tissue, cellular and molecular mechanisms that regulate early regional specification of the vertebrate forebrain are largely unknown. We studied the expression patterns of Xbf-1, an anterior (and telencephalon) neural-specific winged helix transcription factor and Fgf-8, an early-secreted factor. This study looked at Xbf-1 and Fgf-8 expression in combination with embryonic grafting experiments and also used beads containing the recombinant Fgf-8 protein to determine these factors' effects… CONTINUE READING

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