The role of the anaphylatoxins in health and disease.

@article{Klos2009TheRO,
  title={The role of the anaphylatoxins in health and disease.},
  author={Andreas Klos and Andrea Joan Tenner and Kay-Ole Johswich and Rahasson R. Ager and Edimara S. Reis and Joerg Koehl},
  journal={Molecular immunology},
  year={2009},
  volume={46 14},
  pages={2753-66}
}
The anaphylatoxin (AT) C3a, C5a and C5a-desArg are generally considered pro-inflammatory polypeptides generated after proteolytic cleavage of C3 and C5 in response to complement activation. Their well-appreciated effector functions include chemotaxis and activation of granulocytes, mast cells and macrophages. Recent evidence suggests that ATs are also generated locally within tissues by pathogen-, cell-, or contact system-derived proteases. This local generation of ATs is important for their… CONTINUE READING
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