The role of the alternative pathway of the complement system in the development of dense deposit disease

  • Maria Asuncion Abrera Abeleda
  • Published 2016

Abstract

Dense Deposit Disease (DDD) causes chronic renal dysfunction which progresses to end-stage renal disease in about half of patients within 10 years of diagnosis. Deficiency of and mutations in complement Factor H (CFH) are associated with the development of DDD, suggesting that dysregulation of the alternative pathway (AP) of the complement cascade is… (More)

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