The role of the alkaline earth ions in anaphylactic histamine secretion.

@article{Foreman1972TheRO,
  title={The role of the alkaline earth ions in anaphylactic histamine secretion.},
  author={John C Foreman and J. L. Mongar},
  journal={The Journal of physiology},
  year={1972},
  volume={224 3},
  pages={753-69}
}
1. Anaphylactic histamine release from rat peritoneal mast cells is dependent on the presence of calcium ions. Graded increase of histamine release occurs as the calcium ion concentration is raised from 0.1 to 1.0 m-mole/l.2. Magnesium antagonizes the effect of calcium. The dissociation constant of the Mg-receptor complex was found to be 9.4 m-mole/l.3. Strontium will replace calcium ions in the activation of anaphylactic histamine release. Graded increase of histamine release occurs when the… CONTINUE READING