The role of the activated macrophage in clearing Listeria monocytogenes infection.

@article{Shaughnessy2007TheRO,
  title={The role of the activated macrophage in clearing Listeria monocytogenes infection.},
  author={Lee M. Shaughnessy and Joel A. Swanson},
  journal={Frontiers in bioscience : a journal and virtual library},
  year={2007},
  volume={12},
  pages={
          2683-92
        }
}
Macrophage activation often contributes to the strong immune response elicited upon infection. The ability of macrophages to become activated was discovered when sub-lethal primary infections of mice with the bacterium Listeria monocytogenes provided protection against secondary infections through non-humoral immunity. L. monocytogenes infect and propagate in macrophages by escaping the phagosome into the cytosol, where they avoid humoral immune mediators. Activated macrophages kill L… Expand
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