The role of the Wnt signalling pathway in colorectal tumorigenesis.

  title={The role of the Wnt signalling pathway in colorectal tumorigenesis.},
  author={J{\"u}rgen Behrens},
  journal={Biochemical Society transactions},
  volume={33 Pt 4},
Colorectal cancer (CRC) is the second largest cause of cancer-related deaths in Western countries. CRC arises from the colorectal epithelium as a result of the accumulation of genetic alterations in defined oncogenes and tumour suppressor genes. Mutations in the tumour suppressor APC (adenomatous polyposis coli) genes occur early in the development of CRC and lead to the stabilization of the Wnt pathway component beta-catenin and to the constitutive activation of Wnt signalling. Stabilizing… CONTINUE READING
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