The role of the T-helper/T-suppressor ratio in the adaptive immune response: a dynamical model

@article{Annibale2018TheRO,
  title={The role of the T-helper/T-suppressor ratio in the adaptive immune response: a dynamical model},
  author={Alessia Annibale and Luise Dziobek-Garrett and H Tari},
  journal={Journal of Physics A: Mathematical and Theoretical},
  year={2018},
  volume={51}
}
Recent experimental studies have suggested the ratio between T-helper and T-suppressor lymphocytes as an index of immunosuppression in HIV, cancer, immunosenescence and inflammatory and auto-immune diseases. However, a quantitative understanding of the impact of this ratio on the immune response has lagged behind data and its validity as a tool for prognostic monitoring or therapeutic target remains an open question. In this work, we use statistical physics and dynamical systems approaches to… 
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References

SHOWING 1-10 OF 211 REFERENCES
T-helper/T-regulator lymphocyte ratio as a new immunobiological index to quantify the anticancer immune status in cancer patients.
TLDR
The evaluation of T-reg cells in terms of their proportion with respect to T-helper cell total number seems to be more appropriate than the simple measurement of their absolute count, in order to quantify cancer-related immunosuppression.
Self-tolerance and Autoimmunity in a Regulatory T Cell Model
TLDR
Irrespective of mechanism, the model predicts that Tregs specific for the autoantigen in question play no role in the system’s qualitative long-term behaviour, but have quantitative effects that could potentially reduce an autoimmune response to sub-clinical levels.
Regulatory T Cells and the Immune Aging Process: A Mini-Review
TLDR
Emerging data suggest that some Treg populations, specifically naturally occurring Tregs, seem to accumulate with advancing age, whereas inducible T Regs appear to be less available in the older host.
A dynamical model of the adaptive immune system: effects of cells promiscuity, antigens and B–B interactions
TLDR
The analysis shows that the higher the fraction of antigens within the host the harder is for the system to sustain parallel signalling to B cells, crucial for the homeostatic control of cell numbers.
A Population Dynamics Analysis of the Interaction between Adaptive Regulatory T Cells and Antigen Presenting Cells
TLDR
The findings suggest that the interaction network studied in this paper plays an essential part in generating and maintaining tolerance against allergens and self-antigens.
New Insights about Treg and Th17 Cells in HIV Infection and Disease Progression
TLDR
This review focuses on the recent findings regarding the role of regulatory T and Th17 cells in the context of HIV infection, highlighting the importance of the balance between these two subsets on disease progression.
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