The role of the SOS response in bacteria exposed to zidovudine or trimethoprim.

@article{Lewin1991TheRO,
  title={The role of the SOS response in bacteria exposed to zidovudine or trimethoprim.},
  author={Charles Lewin and Sebastian Giles Becket Amyes},
  journal={Journal of medical microbiology},
  year={1991},
  volume={34 6},
  pages={
          329-32
        }
}
Trimethoprim was more potent than zidovudine as an inducer of the SOS response in Escherichia coli. The level of induction by each compound initially increased with rising drug concentration and then fell; this effect was less marked with zidovudine than with trimethoprim. The SOS response did not appear to be involved in the inhibition of bacterial multiplication as the MICs of trimethoprim or zidovudine for recA430 and lexA3 mutants, which are unable to induce the SOS response, were identical… CONTINUE READING

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