The role of the SCN5A‐encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders

@article{Verstraelen2015TheRO,
  title={The role of the SCN5A‐encoded channelopathy in irritable bowel syndrome and other gastrointestinal disorders},
  author={T. E. Verstraelen and R. M. T. Bekke and P. Volders and A. Masclee and J. Kruimel},
  journal={Neurogastroenterology \& Motility},
  year={2015},
  volume={27}
}
Gastrointestinal functional and motility disorders, like irritable bowel syndrome (IBS), have a high prevalence in the Western population and cause significant morbidity and loss of quality of life leading to considerable costs for health care. A decade ago, it has been demonstrated that interstitial cells of Cajal and intestinal smooth muscle cells, cells important for gastrointestinal motility, express the sodium channel alpha subunit Nav1.5. In the heart, aberrant variants in this sodium… Expand
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