The role of the Ran GTPase pathway in cell cycle control and interphase nuclear functions.

  • Mary Dasso
  • Published 1995 in Progress in cell cycle research


Ran is a small, highly abundant, nuclear GTPase. Mutants in Ran and in proteins that interact with it disrupt the normal checkpoint control of mitosis with respect to the completion of DNA synthesis. Ran and other components of this pathway are also required for numerous nuclear functions such as RNA export, protein import, RNA processing and DNA… (More)


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