The role of the Polio Virus Receptor and the Herpesvirus entry mediator B genes for the development of MS

  title={The role of the Polio Virus Receptor and the Herpesvirus entry mediator B genes for the development of MS},
  author={Berit Rosche and Sabine Cepok and Susanne Stei and Friederike Vogel and Verena Grummel and Steve Hoffmann and Antje Kroner and Mathias M{\"a}urer and Peter Rieckmann and Norbert Sommer and Bernhard Hemmer},
  journal={Journal of Neuroimmunology},
Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis
The analysis of a very large data set suggests that genetic polymorphisms in PVRL2 may influence MS severity and supports the possibility that viral factors may contribute to the clinical course of MS, consistent with previous reports.
Members 6B and 14 of the TNF receptor superfamily in multiple sclerosis predisposition
Both polymorphisms were associated with MS predisposition, with stronger effect in patients with HHV6 active replication—TNFRSF6B-rs4809330*A: P=0.028, OR=1.13; TNF RSF14-rs6684865*A; and HHV 6-positive patients vs controls: P =0.017, OR =1.69.
Ala67Thr Mutation in the Human Polio Virus Receptor (PVR) Gene inPost-Polio Syndrome Patients
Clinical and demographic characteristics of the PPS individuals who were affected initially by poliomyelitis and later developed PPS are presented and changes in the PVR gene may result in slowly progressive cytopathic effects that may lead to progression of PPS.
Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild‐type paralytic poliomyelitis
It is concluded that the Ala67Thr mutation in the poliovirus receptor is a possible risk factor for the development of vaccine‐associated or paralytic poliomyelitis associated with wild‐type virus.
Association analysis of the poliovirus receptor related-2 gene in patients with nonsyndromic cleft lip with or without cleft palate.
The hypothesis that this poliovirus receptor related-2 (PRR2) gene contributes to the risk of nsCL/P is supported, suggesting a possible etiologic role of PRR2 in nsCL /P.
The genetics of clinical outcome in multiple sclerosis
No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis


The human poliovirus receptor related 2 protein is a new hematopoietic/endothelial homophilic adhesion molecule.
A monoclonal antibody directed against the Poliovirus Receptor Related 2 extracellular region suggests that homophilic properties of PRR2 could participate to the regulation of hematopoietic/endothelial cell functions.
New concepts in the immunopathogenesis of multiple sclerosis
Recent advances in understanding of the pathogenesis of MS are summarized, and an outlook on how to capitalize on this knowledge to develop new therapeutic approaches is concluded.
Multiple sclerosis: Genomic rewards
Association of polymorphisms in the apolipoprotein E region with susceptibility to and progression of multiple sclerosis.
Using family-based association analysis, statistically significant evidence is found that an SNP haplotype near APOE is associated with MS susceptibility and an analysis of disease progression in 614 patients with MS from 379 families indicated that APOE-4 carriers are more likely to be affected with severe disease.
Monoclonal antibody identification of a 100-kDa membrane protein in HeLa cells and human spinal cord involved in poliovirus attachment.
Results strongly suggest that the 100-kDa band detected by antibody AF3 is, or is closely associated with, the poliovirus receptor site.
Linkage and association analysis of chromosome 19q13 in multiple sclerosis
Support for an MS susceptibility locus was observed, primarily in families with the MS-associated HLA-DR2 allele, and this effect appears to be modest with a maximum λS=1.47, probably representing no more than 10% of the overall genetic effect in MS.
A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus.
Differences in ability of HSV-1 andHSV-2 strains to use HveB for entry should influence the types of cells that can be infected and thereby account in part for serotype and strain differences in tissue tropism and pathogenicity.