The role of the Polio Virus Receptor and the Herpesvirus entry mediator B genes for the development of MS

@article{Rosche2004TheRO,
  title={The role of the Polio Virus Receptor and the Herpesvirus entry mediator B genes for the development of MS},
  author={Berit Rosche and Sabine Cepok and Susanne Stei and Friederike Vogel and Verena Grummel and Steve Hoffmann and Antje Kroner and Mathias M{\"a}urer and Peter Rieckmann and Norbert Sommer and Bernhard Hemmer},
  journal={Journal of Neuroimmunology},
  year={2004},
  volume={156},
  pages={171-177}
}
Allelic association of sequence variants in the herpes virus entry mediator-B gene (PVRL2) with the severity of multiple sclerosis
TLDR
The analysis of a very large data set suggests that genetic polymorphisms in PVRL2 may influence MS severity and supports the possibility that viral factors may contribute to the clinical course of MS, consistent with previous reports.
Members 6B and 14 of the TNF receptor superfamily in multiple sclerosis predisposition
TLDR
Both polymorphisms were associated with MS predisposition, with stronger effect in patients with HHV6 active replication—TNFRSF6B-rs4809330*A: P=0.028, OR=1.13; TNF RSF14-rs6684865*A; and HHV 6-positive patients vs controls: P =0.017, OR =1.69.
Ala67Thr Mutation in the Human Polio Virus Receptor (PVR) Gene inPost-Polio Syndrome Patients
TLDR
Clinical and demographic characteristics of the PPS individuals who were affected initially by poliomyelitis and later developed PPS are presented and changes in the PVR gene may result in slowly progressive cytopathic effects that may lead to progression of PPS.
Ala67Thr mutation in the poliovirus receptor CD155 is a potential risk factor for vaccine and wild‐type paralytic poliomyelitis
TLDR
It is concluded that the Ala67Thr mutation in the poliovirus receptor is a possible risk factor for the development of vaccine‐associated or paralytic poliomyelitis associated with wild‐type virus.
Association analysis of the poliovirus receptor related-2 gene in patients with nonsyndromic cleft lip with or without cleft palate.
TLDR
The hypothesis that this poliovirus receptor related-2 (PRR2) gene contributes to the risk of nsCL/P is supported, suggesting a possible etiologic role of PRR2 in nsCL /P.
The genetics of clinical outcome in multiple sclerosis
No effect of APOE and PVRL2 on the clinical outcome of multiple sclerosis

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