The role of the PD-L1:PD-1 pathway in squamous cell carcinoma of the head and neck.

@article{Zandberg2014TheRO,
  title={The role of the PD-L1:PD-1 pathway in squamous cell carcinoma of the head and neck.},
  author={Dan P Zandberg and Scott E. Strome},
  journal={Oral oncology},
  year={2014},
  volume={50 7},
  pages={627-32}
}
Antigen specific stimulation of immune cells, triggers expression of a diverse array of co-signaling molecules that help define the fate of the resultant immune response. Antibodies and fusion proteins, capable of blocking and/or activating these co-signaling pathways, are emerging as potent therapeutic options for the treatment of cancer and autoimmune disease. Blockade of one such pair of co signaling interactions, termed PD-L1:PD-1, has shown tremendous promise in phase I treatment trials… CONTINUE READING
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