The role of the PD-1 pathway in autoimmunity and peripheral tolerance.

@article{Fife2011TheRO,
  title={The role of the PD-1 pathway in autoimmunity and peripheral tolerance.},
  author={Brian T Fife and Kristen E. Pauken},
  journal={Annals of the New York Academy of Sciences},
  year={2011},
  volume={1217},
  pages={45-59}
}
Programmed death-1 (PD-1) is a surface receptor critical for the regulation of T cell function during immunity and tolerance. PD-1 interactions with its ligands PD-L1 and PD-L2 inhibit T cell effector functions in an antigen-specific manner. This paper examines the role of PD-1 in limiting autoreactivity and establishing self-tolerance and discusses the hypothesis that PD-1 ligand (PD-L) expression both spatially and temporally dictates the fate of self-reactive T cells during the breakdown of… CONTINUE READING

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