The role of the NO pathway in the control of cardiac function.

@article{Smith1996TheRO,
  title={The role of the NO pathway in the control of cardiac function.},
  author={Thomas W. Smith and Jean-Luc Balligand and David M. Kaye and Stephen D. Wiviott and William W. Simmons and Xiaoyan Han and Thomas Michel and Krishna Singh and Ralph A. Kelly},
  journal={Journal of cardiac failure},
  year={1996},
  volume={2 4 Suppl},
  pages={S141-7}
}
Nitric oxide (NO) acts as an autocrine- and paracrine-acting signaling autacoid that, among other functions, has been shown to regulate cardiac contractile responsiveness to beta-adrenergic and muscarinic cholinergic agonists. Nitric oxide (NO) is formed by the oxidation of one of two equivalent guanidino nitrogens in L-arginine by O2 to form NO and L-citrulline. This reaction is catalyzed by a family of enzymes termed NO synthases. Three distinct isoforms of NOS have been identified, each the… CONTINUE READING