The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease.

@article{Stve2002TheRO,
  title={The role of the MHC class II transactivator in class II expression and antigen presentation by astrocytes and in susceptibility to central nervous system autoimmune disease.},
  author={Olaf St{\"u}ve and Sawsan S Youssef and Anthony J. Slavin and Chelsea L. King and Juan Carlos Patarroyo and David L. Hirschberg and Willie June Brickey and Jeanne M. Soos and Janet F. Piskurich and Harold A Chapman and Scott S. Zamvil},
  journal={Journal of immunology},
  year={2002},
  volume={169 12},
  pages={6720-32}
}
The role of the MHC class II transactivator (CIITA) in Ag presentation by astrocytes and susceptibility to experimental autoimmune encephalomyelitis (EAE) was examined using CIITA-deficient mice and newly created transgenic mice that used the glial fibrillary acidic protein promoter to target CIITA expression in astrocytes. CIITA was required for class II expression on astrocytes. Like class II-deficient mice, CIITA-deficient mice were resistant to EAE by immunization with CNS autoantigen… CONTINUE READING

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De novo CNS processing of myelin antigen is required for the initiation of EAE

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