The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.

@article{Usui2006TheRO,
  title={The role of the ICOS/B7RP-1 T cell costimulatory pathway in murine experimental autoimmune uveoretinitis.},
  author={Yoshihiko Usui and Hisaya Akiba and Masaru Takeuchi and Takeshi Kezuka and Aya Takeuchi and Takaaki Hattori and Yoko Okunuki and Tomohide Yamazaki and H. Yagita and Masahiko Usui and Ko Okumura},
  journal={European journal of immunology},
  year={2006},
  volume={36 11},
  pages={3071-81}
}
ICOS/B7RP-1 is a new member of the CD28/B7 family of costimulatory molecules and plays differential roles in autoimmune diseases. In this study, we examined the role of ICOS/B7RP-1 pathway in the pathogenesis of mouse experimental autoimmune uveoretinitis (EAU), an animal model of human autoimmune uveitis. ICOS expression was found on infiltrating CD4+ T cells in the region of the retina in EAU-induced mice. The anti-B7RP-1 monoclonal antibody (mAb)-treated or ICOS-deficient mice showed a… CONTINUE READING

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