The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels.

@article{Raybaud2006TheRO,
  title={The role of the GX9GX3G motif in the gating of high voltage-activated Ca2+ channels.},
  author={Alexandra Raybaud and Yolaine Dodier and Pierre Bissonnette and Manuel Sobrinho Sim{\~o}es and Daniel Georges Bichet and R{\'e}my Sauv{\'e} and Lucie Parent},
  journal={The Journal of biological chemistry},
  year={2006},
  volume={281 51},
  pages={39424-36}
}
The putative hinge point revealed by the crystal structure of the MthK potassium channel is a glycine residue that is conserved in many ion channels. In high voltage-activated (HVA) Ca(V) channels, the mid-S6 glycine residue is only present in IS6 and IIS6, corresponding to G422 and G770 in Ca(V)1.2. Two additional glycine residues are found in the distal portion of IS6 (Gly(432) and Gly(436) in Ca(V)1.2) to form a triglycine motif unique to HVA Ca(V) channels. Lethal arrhythmias are associated… CONTINUE READING

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