The role of the G2 box, a conserved motif in the histidine kinase superfamily, in modulating the function of EnvZ.

@article{Zhu2002TheRO,
  title={The role of the G2 box, a conserved motif in the histidine kinase superfamily, in modulating the function of EnvZ.},
  author={Yan Zhu and M. Inouye},
  journal={Molecular microbiology},
  year={2002},
  volume={45 3},
  pages={653-63}
}
Histidine kinase EnvZ, a transmembrane osmotic sensor for Escherichia coli, is a bifunctional enzyme having OmpR (its cognate response regulator) kinase and phosphorylated OmpR (OmpR-P) phosphatase activities. Its cytoplasmic domain consists of domain A responsible for dimerization of EnvZ, histidine phosphotransfer and phosphatase activities, and domain B responsible for ATP binding. Here, we have constructed a number of substitution mutations at the G2 box, one of the conserved motifs in… CONTINUE READING

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