The role of the FOXP3 transcription factor in the immune regulation of allergic asthma.

Abstract

Unbalanced immune reactions against allergens are caused by Th2 cells, which are the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. Although Th2 cells are essential for allergy, they are not sufficient to cause disease, because regulatory T cells (Tregs) control their activity and expansion. Therefore, Tregs are assumed to play an important role not only in the sensitization but also in established allergic disease under therapy. A key factor of Tregs is FOXP3, which, upon expression, is sufficient to induce regulatory T-cell phenotypes. The initiation and suppressive function of FOXP3 and Tregs in the context of allergic asthma are discussed in this review.

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@article{SchmidtWeber2005TheRO, title={The role of the FOXP3 transcription factor in the immune regulation of allergic asthma.}, author={Carsten B. Schmidt-Weber and Kurt Blaser}, journal={Current allergy and asthma reports}, year={2005}, volume={5 5}, pages={356-61} }