The role of the FOXP3 transcription factor in the immune regulation of allergic asthma

  title={The role of the FOXP3 transcription factor in the immune regulation of allergic asthma},
  author={Carsten B. Schmidt‐Weber and Kurt Blaser},
  journal={Current Allergy and Asthma Reports},
Unbalanced immune reactions against allergens are caused by Th2 cells, which are the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. Although Th2 cells are essential for allergy, they are not sufficient to cause disease, because regulatory T cells (Tregs) control their activity and expansion. Therefore, Tregs are assumed to play an important role not only in the sensitization but also in established allergic disease under therapy. A key factor of Tregs is FOXP3, which… 
Foxp3 expressing regulatory T-cells in allergic disease.
  • K. Nouri-Aria
  • Biology, Medicine
    Advances in experimental medicine and biology
  • 2009
Activation and expansion ofantigen-specific CD4+CD25+ Tregs in vivo using adjuvants such as IL-10 or pharmacological agents such as low dose steroids or vitamin D3 could represent novel approaches to induce antigen-specific tolerance in immune-mediated conditions such as allergic asthma, autoimmune disease and the rejection of transplanted organs in man.
The Role of TGF-b in Allergic Inflammation
TGF-b was shown to induce Tregs and participate directly in suppression of effector T cells (Teffs) and may help return reactivity to allergens to normal subsymptomatic activity, and future strategies in this field are addressed.
The anti-inflammatory properties of intravenous immunoglobulin in a murine model of allergic airway disease ; effects on the development of regulatory T-cells
Using a robust antigen-driven model of allergic airway disease, IVIg markedly attenuates airway inflammation and this effect is associated with the induction of Tregs from non-regulatory T cells in pulmonary tissues, and it is demonstrated that the antiinflammatory actions of IVIG are dependent on a population of pulmonary CD11c + dendritic cells (DCs).
Gesunde und allergische Immunantwort unterscheiden sich durch die Anzahl spezifischer Treg-Zellen
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OX40/OX40 Ligand Interactions in T-Cell Regulation and Asthma
Targeting the OX40/OX40L axis or TSLP presents a novel therapeutic strategy that has the potential of modifying the disease process and, therefore, impacting on its natural history.
Novel Allergen Immunotherapy Routes
The authors concluded, that EPIT is safe and efficacious in a dose-dependent manner after six patches only, and is a possible alternative application form for IgE-mediated allergic diseases.


Immunological mechanisms of specific allergen immunotherapy.
The mechanisms underlying the balance of these cell populations along with suppressive mechanisms of SIT are reviewed, which may serve as future drug targets.
Glucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma.
Control of Regulatory T Cell Development by the Transcription Factor Foxp3
Foxp3, which encodes a transcription factor that is genetically defective in an autoimmune and inflammatory syndrome in humans and mice, is specifically expressed in naturally arising CD4+ regulatory T cells and retroviral gene transfer of Foxp3 converts naïve T cells toward a regulatory T cell phenotype similar to that of naturally occurring CD4+.
Immunological mechanisms in specific immunotherapy
The current review provides an overview on the mechanisms of SIT and possible adjuvant treatment strategies on the background of the T reg concept.
IL‐10 and TGF‐β cooperate in the regulatory T cell response to mucosal allergens in normal immunity and specific immunotherapy
A deviation towards a regulatory/suppressor T cell response during SIT and in normal immunity as a key event for the healthy immune response to mucosal antigens is demonstrated.
Immune Responses in Healthy and Allergic Individuals Are Characterized by a Fine Balance between Allergen-specific T Regulatory 1 and T Helper 2 Cells
The mechanisms by which immune responses to nonpathogenic environmental antigens lead to either allergy or nonharmful immunity are unknown. Single allergen-specific T cells constitute a very small
Scurfin (FOXP3) Acts as a Repressor of Transcription and Regulates T Cell Activation*
The findings indicate that the ability of scurfin to bind DNA, and presumably repress transcription, plays a paramount role in determining the amplitude of the response of CD4 T cells to activation.