The role of the FOXP3 transcription factor in the immune regulation of allergic asthma

@article{SchmidtWeber2005TheRO,
  title={The role of the FOXP3 transcription factor in the immune regulation of allergic asthma},
  author={Carsten B. Schmidt‐Weber and Kurt Blaser},
  journal={Current Allergy and Asthma Reports},
  year={2005},
  volume={5},
  pages={356-361}
}
Unbalanced immune reactions against allergens are caused by Th2 cells, which are the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. Although Th2 cells are essential for allergy, they are not sufficient to cause disease, because regulatory T cells (Tregs) control their activity and expansion. Therefore, Tregs are assumed to play an important role not only in the sensitization but also in established allergic disease under therapy. A key factor of Tregs is FOXP3, which… 
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Foxp3 expressing regulatory T-cells in allergic disease.
  • K. Nouri-Aria
  • Biology, Medicine
    Advances in experimental medicine and biology
  • 2009
TLDR
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Using a robust antigen-driven model of allergic airway disease, IVIg markedly attenuates airway inflammation and this effect is associated with the induction of Tregs from non-regulatory T cells in pulmonary tissues, and it is demonstrated that the antiinflammatory actions of IVIG are dependent on a population of pulmonary CD11c + dendritic cells (DCs).
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