The role of the FOXP3 transcription factor in the immune regulation of allergic asthma
@article{SchmidtWeber2005TheRO, title={The role of the FOXP3 transcription factor in the immune regulation of allergic asthma}, author={Carsten B. Schmidt‐Weber and Kurt Blaser}, journal={Current Allergy and Asthma Reports}, year={2005}, volume={5}, pages={356-361} }
Unbalanced immune reactions against allergens are caused by Th2 cells, which are the basis of immunoglobulin E (IgE)-mediated symptoms of allergy and asthma. Although Th2 cells are essential for allergy, they are not sufficient to cause disease, because regulatory T cells (Tregs) control their activity and expansion. Therefore, Tregs are assumed to play an important role not only in the sensitization but also in established allergic disease under therapy. A key factor of Tregs is FOXP3, which…
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