The role of the EP receptors for prostaglandin E2 in skin and skin cancer

@inproceedings{Rundhaug2011TheRO,
  title={The role of the EP receptors for prostaglandin E2 in skin and skin cancer},
  author={Joyce E. Rundhaug and Melissa Sue Simper and Inok Surh and Susan M. Fischer},
  booktitle={Cancer and Metastasis Reviews},
  year={2011}
}
One of the most common features of exposure of skin to ultraviolet (UV) light is the induction of inflammation, a contributor to tumorigenesis, which is characterized by the synthesis of cytokines, growth factors and arachidonic acid metabolites, including the prostaglandins (PGs). Studies on the role of the PGs in non-melanoma skin cancer (NMSC) have shown that the cyclooxygenase-2 (COX-2) isoform of the cyclooxygenases is responsible for the majority of the pathological effects of PGE2. In… CONTINUE READING
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