The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism.

@article{SotoRifo2013TheRO,
  title={The role of the DEAD-box RNA helicase DDX3 in mRNA metabolism.},
  author={Ricardo Soto-Rifo and Th{\'e}ophile Ohlmann},
  journal={Wiley interdisciplinary reviews. RNA},
  year={2013},
  volume={4 4},
  pages={369-85}
}
DDX3 belongs to the DEAD-box proteins, a large family of ATP-dependent RNA helicases that participate in all aspects of RNA metabolism. Human DDX3 is a component of several messenger ribonucleoproteins that are found in the spliceosome, the export and the translation initiation machineries but also in different cytoplasmic mRNA granules. DDX3 has been involved in several cellular processes such as cell cycle progression, apoptosis, cancer, innate immune response, and also as a host factor for… CONTINUE READING