Corpus ID: 3027077

The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.

@article{Chen2001TheRO,
  title={The role of the D(2) dopamine receptor (D(2)R) in A(2A) adenosine receptor (A(2A)R)-mediated behavioral and cellular responses as revealed by A(2A) and D(2) receptor knockout mice.},
  author={Jinhui Chen and Rosario Moratalla and Francesco Impagnatiello and David K. Grandy and Beatriz Verduzco Cu{\'e}llar and Marcelo Gonçalves Rubinstein and Michael A. Beilstein and Elizabeth Hackett and J. Stephen Fink and Malcolm J Low and Ennio Ongini and Michael A Schwarzschild},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2001},
  volume={98 4},
  pages={
          1970-5
        }
}
  • Jinhui Chen, Rosario Moratalla, +9 authors Michael A Schwarzschild
  • Published in
    Proceedings of the National…
    2001
  • Medicine
  • The A(2A)R is largely coexpressed with D(2)Rs and enkephalin mRNA in the striatum where it modulates dopaminergic activity. Activation of the A(2A)R antagonizes D(2)R-mediated behavioral and neurochemical effects in the basal ganglia through a mechanism that may involve direct A(2A)R-D(2)R interaction. However, whether the D(2)R is required for the A(2A)R to exert its neural function is an open question. In this study, we examined the role of D(2)Rs in A(2A)R-induced behavioral and cellular… CONTINUE READING

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