The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii.

Abstract

We examined the role of the CD28/B7 interaction in regulation of NK cell activity. Cells transfected with B7 enhanced IL-12-induced production of IFN-gamma by IL-2-activated, CD28+ NK cells, but not by resting CD28- NK cells. The ability of B7 transfectants to enhance NK cell production of IFN-gamma was dependent on the intracellular adhesion molecule-1/LFA… (More)

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@article{Hunter1997TheRO, title={The role of the CD28/B7 interaction in the regulation of NK cell responses during infection with Toxoplasma gondii.}, author={Catherine Hunter and L Ellis-Neyer and Kathleen Gabriel and M. K. Kennedy and Kenneth H. Grabstein and Peter S. Linsley and Jack S. Remington}, journal={Journal of immunology}, year={1997}, volume={158 5}, pages={2285-93} }