The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics.

@article{Fang2008TheRO,
  title={The role of the C terminus of the SNARE protein SNAP-25 in fusion pore opening and a model for fusion pore mechanics.},
  author={Qinghua Fang and Khajak Berberian and Liang-wei Gong and Ismail Hafez and Jakob Balslev S\orensen and Manfred Lindau},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2008},
  volume={105 40},
  pages={15388-92}
}
Formation of a fusion pore between a vesicle and its target membrane is thought to involve the so-called SNARE protein complex. However, there is no mechanistic model explaining how the fusion pore is opened by conformational changes in the SNARE complex. It has been suggested that C-terminal zipping triggers fusion pore opening. A SNAP-25 mutant named SNAP-25Delta9 (lacking the last nine C-terminal residues) should lead to a less-tight C-terminal zipping. Single exocytotic events in chromaffin… CONTINUE READING

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