The role of the Bcl-2 protein family in cancer.

@article{Coultas2003TheRO,
  title={The role of the Bcl-2 protein family in cancer.},
  author={Leigh Coultas and Andreas Strasser},
  journal={Seminars in cancer biology},
  year={2003},
  volume={13 2},
  pages={115-23}
}
Seminal studies on the proto-oncogene bcl-2 have first demonstrated that mutations that inhibit programmed cell death (apoptosis) can promote lymphomagenesis and influence the sensitivity of tumour cells to chemotherapy or radiotherapy. It is now widely believed that neoplastic transformation of many, perhaps even all, cell types requires mutational changes that interfere with the cell death programme. In this review, we describe current knowledge of the molecular control of cell death and… CONTINUE READING

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